OXA-253, a Variant of the Carbapenem-Hydrolyzing Class D -Lactamase OXA-143 in Acinetobacter baumannii
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منابع مشابه
OXA-253, a variant of the carbapenem-hydrolyzing class D β-lactamase OXA-143 in Acinetobacter baumannii.
The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 gene shares the highest identity with ubiquitous GR2 group plasmids usually ca...
متن کاملFirst report of OXA-143-lactamase producing Acinetobacter baumannii inQom
Objective(s):Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, 108 non-duplic...
متن کاملOXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii.
OBJECTIVES Acinetobacter baumannii is a significant pathogen in health care settings. In recent years, an increase in carbapenem resistance among A. baumannii due to Ambler class B metallo-beta-lactamases or class D OXA carbapenamases has been reported. In this study we detected the presence of OXA carbapenamases and coproduction of metallo-beta-lactamases (blaVIM and blaIMP ) by phenotypic and...
متن کاملCarbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
The basis of the beta-lactam resistance of 39 multidrug-resistant Acinetobacter baumannii isolates recovered from hospitalized patients was studied. These isolates were collected from 2001 to 2005 at the Sahloul Hospital in Sousse, Tunisia. They belonged to two distinct clones. One clone that grouped 19 isolates produced a carbapenem-hydrolyzing oxacillinase, OXA-97, that differed from OXA-58 b...
متن کاملFirst report of the carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter baumannii isolates in Italy.
Emergence of Acinetobacter baumannii with resistance or reduced susceptibility to carbapenems has been reported worldwide (4). Acinetobacter may develop resistance to carbapenems through various mechanisms, including decreased permeability, efflux pump overexpression, and production of carbapenemases (3, 4, 9). Four of the eight carbapenemase-hydrolyzing oxacillinase (OXA) clusters have been id...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02640-13